The incidence rate of cerebrovascular disease(CVD) increased in post-menopause women, due to losing protection of endogenous estrogen.

绝经后女性脑血管病发生率上升是由于失去了内源性雌激素的保护作用。

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Unfortunately, these losses have coincided with a decline in R&D productivity: the drugs discovered in the labs are not replacing the value of those medicines losing patent protection.

不幸的是，这种损失恰逢研发生产力的衰退：实验室里研发出药物无法取代那些失去专利保护的药物。

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He works with his neighbours to build shelters for the alpaca to give some protection from the elements, but he is fighting a losing battle.

他正和邻居们一起给羊驼建造茅屋，抵御天气变化。可是，他打的却是一场必败的仗。

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Most of Pfizer's big sellers are aging, with many losing patent protection, causing sales to crumble.

FORBES: Pfizer's New Blockbuster Drug

Merck is losing patent protection in some countries on Zocor, its top-selling cholesterol medication.

FORBES: For Merck, Steps In The Right Direction

This is a common strategy for companies trying to replace a blockbuster that is losing patent protection.

FORBES: Forest Bears Fruit