The current recommended second-line treatment regimens are complex, of long duration, and require intensive monitoring of adverse events and treatment outcomes.

目前建议采用的二线治疗方案程序复杂、疗程过长，并需要密切监测不良事件和治疗结果。

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Local fixed-line calls now cost a flat 1.5 pesos ($0.12) if billed individually, regardless of duration, similar to prices elsewhere in Latin America.

现在，墨西哥本地固定电话收费采用类似拉美其它地区的政策-不管通话时间多长，都以 1.5 比索(0.12美元) 封顶。

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bottom line is that adequate recovery-sleep duration is important for coping with the effects of chronic sleep restriction on the brain.

“说到底，充足的恢复性睡眠有助于消除长时间睡眠不足给大脑所带来的副作用”。

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That frustration will evaporate in 2016 when the new FasTracks East Rail Line will cut the duration of the 25-mile trip between downtown and the newly renovated Union Station to just 30 minutes.

BBC: Business trip: Denver

"The bottom line is clinicians must take all clinical parameters into account for the patient and prescribe the lowest dose for the shortest duration of time, " said Dr. Joseph Sanfilippo, vice chairman of reproductive sciences at Magee-Women's Hospital in Pittsburgh, in an e-mail to CNN.

CNN: Government panel: Hormone therapy 'not recommended'