Depression is one of the leading problems of human mental imbalance and a common occur rence, which has an immeasurable negative impact on individual's physical and mental health, work and life.

抑郁是人类心理失调最主要和最经常出现的问题之一，对个体的身心健康、工作生活都会造成不可低估的负面影响。

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The researchers disagree with the World Health Organization which says blindness and other vision problems are the leading cause.

VOA: special.2009.12.28

Uncorrected cases of near-sightedness, far-sightedness and astigmatism are the leading cause of vision problems.

VOA: special.2011.05.16

Toyota's problems come amid a growing number of complaints, accidents,recalls and financial problems for several leading Japanese companies.

VOA: standard.2010.02.15

In addition, as far as the prenatal environment per hormonal influences, there is some evidence that sexual, physical or verbal abuse could be factors rising to the level of stress that might alter the hormonal prenatal environment, leading to problems in neurodevelopment.

FORBES: Abuse Of Mom In Childhood And Autism Risk

In turn, such stepped-up oversight only uncovers more problems leading to more recalls.

FORBES: A Survival Map in the Age of Product Recalls

The first minister said discussions are taking place with local health managers to tackle any problems leading to inappropriate delays.

BBC: Photo of Scottish flag