However, existing HDAC inhibitors can exhibit low potency, lack of selectivity, and poor pharmacokinetic or toxicity profiles.

但现有HDAC抑制剂效度低、缺乏选择性、药代动力学或毒性特征较差。

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The lack of similar potency amongst the current crop of Australian bowlers - including Ben Hilfenhaus, Mitchell Johnson, Doug Bollinger and spinner Nathan Hauritz - has strengthened English hopes of a first series win down under since 1987.

BBC: Ashes series: Michael Vaughan criticises Aussie attack

Former World Cup winning captain Johnson, widely criticized after the defeat by Australia and a disappointing win over Argentina, picked a physical side to combat the All Blacks but his team ultimately paid for a lack of attacking potency.

CNN: Scotland claim historic Wallabies scalp