In the safety study, a 52-week open-label trial, Dr. Wortzman and colleagues reported clindamycin-tretinoin gel to be safe and well tolerated in 655 patients (mean age, 20 years).

在52周的开放性安全试验中，Wortzman博士及其同事报告，655名患者(平均年龄20岁)使用克林霉素-维甲酸凝胶显示安全有效且耐受良好。

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Obviously, an unblinded trial design (also known as an open-label trial) represents a particularly high-risk approach when the outcome involves a subjective assessment by either the patient or the physician.

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The study was a multinational, single-arm, open-label, 78 week trial that was recently published in the November 2, 2012 online version of the Lancet.

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Despite some limitations of trial design, including the open label nature of the study, RECORD remains the only randomized trial of cardiovascular outcomes for Avandia at this time.

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