This paper introduced the principle, the targeting strategies, the screening mechanism and the commonly method in animals, plants and micro-organisms of gene knockout.
本文简述了基因敲除技术的基本原理、打靶策略、筛选机制，在动植物和微生物中常用的基因敲除方法以及基因敲除的应用。
The reaction of anticancer drug LDM with PML-wild-type and-knockout cells may elucidate that its not the unique pathway in the mechanism of LDM's action on normal and cancer cells.
PML野生型和基因敲除细胞对抗癌药物LDM的反应提示正常细胞和癌细胞对抗肿瘤药物反应过程中PML蛋白不是唯一的途径。
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