The Wildcats crossed early on through JamieRooney but tries from Danny Orr, Matt Gafa, Michael Worrincy and Rikki Sheriffe gave Harlequins a 20-6 lead.
England are already missing a host of players, including Paul Robinson, John Terry, Wayne Bridge, Rio Ferdinand, Jamie Carragher, Ledley King, Steven Gerrard, Frank Lampard, Kieron Dyer and Wayne Rooney.