Conclusion JAK2 exon 12 mutations could exist in JAK2V617F-negative PV patients.

结论JAK2V 617 F点突变阴性的PV患者中存在JAK2外显子12突变。

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JAK2 is a constitutive protein tyrosine kinase (PTK) which can activate JAK-STAT signaling.

JAK2是一种组成性酪氨酸激酶，能激活JAK - STAT信号传导途径。

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"Those children at the highest risk for leukemia may be treated with inhibitors of JAK2," he says.

他说：“这些患有高致命性白血病的儿童可以用JAK2抑制剂进行治疗。”

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But Rosen's foundation can pay his lab for its work with companies such as Exelixis and TargeGen that are testing anti-JAK2 drugs.

FORBES: Magazine Article

That meant that JAK2-blocking drugs might work for patients like Pritzker, too.

FORBES: Patient Power

The first time the group of researchers met, he piped up with research showing that mutations in genes related to JAK2 could also cause the disease.

FORBES: Patient Power