What's the matter? Is there something wrong?

怎么了？出了什么事儿吗？

《牛津词典》

Is there something wrong with your eye?

你的眼睛有什么问题吗？

youdao

A: Is there something wrong? You look so sad.

出什么事了吗？你好像很伤心。

youdao

I just... Is there something wrong with that beach?

VOA: standard.other

We don't give ourselves the permission to be human, because we think there is something wrong with us if we experience these emotions.

我们不准许自己为人，因为我们觉得是自己有毛病,如果我们有这样的情绪。

哈佛公开课 - 幸福课课程节选

In the late eighteen eighties, a North Carolina farming publication described America's economy this way: "There is something radically wrong in our industrial system.

VOA: special.2010.06.10

Is there something wrong with this company that I should be worried about?

FORBES: Great Employees Are Not Replaceable

Is that the right color orange, or is there something wrong with that?

WSJ: Creating: A Daring Designer of Snazzy Snacks

Is there something wrong with being a Muslim in this country?

CNN: Commentary: Candidates should seek votes of Muslim-Americans