Catherine, contented at first, in a brief space grew irritable and restless.

凯瑟琳，起初满足了，不久就变得暴躁不安。

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Sometimes Tim Loughton seems a little irritable.

BBC: An elaborate ritual

Similarly, a former college athlete who becomes angry and irritable in his 40s could be suffering a midlife crisis or delayed reaction to head injuries sustained decades earlier.

WSJ: Confusing Medical Ailments With Mental Illness

Of those, only Lotronex, a treatment for irritable-bowel syndrome in women, has been re-introduced.

ECONOMIST: The best medicine? | The