以上来源于: WordNet
This analysis reaffirms the emerging nature of IRAK4, NIK, Tyk2, ZAP-70 as intriguing targets.
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IRAK4 is a critical signaling protein downstream of IL1R, IL18R, IL33R, and a set of Toll-Like Receptors.
Furthermore, a human mutation leading to IRAK4-deficient individuals has been well characterized.
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