Carotenes are insoluble in water and soluble in oils and fats.

胡萝卜素不溶于水，但溶于油和脂肪。

《柯林斯英汉双解大词典》

Oil is insoluble in water.

油不溶于水。

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It is insoluble in ethanol and carbon disulfide.

不溶于乙醇和二硫化碳。

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Today David Obey said he wasn't sure how he was going to deal with the supplemental request because he was afraid the administration would be -- in his words -- devoured by an insoluble problem in Pakistan and Afghanistan.

WHITEHOUSE: White House Press Briefing

Like other iron minerals, green rust readily absorbs dissolved elements onto its surface, but green rust is not only particularly efficient at this in many cases, it can also react with toxic dissolved trace metals to make them insoluble, and as a result, renders them in nontoxic forms.

MSN: What green rust did long ago to the big blue ocean

Because the choices really are often insoluble and the losses are often so actual, we in the mental health professions frequently try to find "a third way" to help people cope.

CNN: When the holidays turn depressing