Fragile X syndrome, a single genetic mutation on the X chromosome, is the most common source of inherited mental impairment, affecting one in every 4,000 boys and one in every 6,000 girls.

脆性X综合征，一个X染色体上的基因突变，是遗传性智力障碍最常见的来源，每4000名男孩和每6000名女孩中就有一名儿童患有该症。

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Fragile X syndrome, a single genetic mutation on the X chromosome, is the most common source of inherited mental impairment, affecting one in every 4, 000 boys and one in every 6, 000 girls.

脆性X综合征，一个X染色体上的基因突变，是遗传性智力障碍最常见的来源，每4000名男孩和每6000名女孩中就有一名儿童患有该症。

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People who inherited the mutations are much more likely to develop restless leg syndrome, the researchers report in the journal PLoS Genetics.

最近，科学家发现，两种基因突变和不宁腿综合征（restless leg syndrome ，RLS）有关，遗传这种基因突变的人更容易发生不宁腿综合征。

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Bear's work suggests that a specific class of drug already sitting on drug company shelves may help patients with an inherited disease called fragile X syndrome, a common cause of autism.

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The study, which tracked 1000 patients in 16 countries for more than four years, was conducted by researchers from Queens University and Newcastle University in the UK. They focused principally on people with Lynch syndrome, an inherited genetic disorder that causes cancer by affecting genes responsible for detecting and repairing DNA damage.

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Compounds in preclinical tests target cystic fibrosis (30, 000 people plus a thousand new cases per year), Huntington's disease (30, 000 cases) and Rett syndrome, a rare inherited brain disorder.

FORBES: Magazine Article