"Embryonic stem cells can pretty much be predicted," says Zhang. "Induced cells cannot. That means that at this point there is still some work to be done to generate ideal induced pluripotent stem cells for application."
CONCLUSION: ATRAcannotinduceHL60 to achieveterminaldifferentiation, but the differentiation of HL 60 can beinduced by ATRA and the differentiatedleukemiacells are easy toapoptosis.