吲哚胺-2,3双加氧酶(Indoleamine 2, 3-xygenase, IDO),是色氨酸分解代谢的限速酶,可在局部形成低色氨酸环境。DC表达IDO参与了机体的免疫耐受。
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Backgroud: Indoleamine- 2, 3 -Dioxygenase(INDO) is one of the rate-limiting enzyme in tryptophan catabolism, which can induce region immune tolerance by many mechanism after its expression is enhanced, to create the suitable condition for development of tumor.
背景:吲哚胺-2,3-双加氧酶(INDO)是人体细胞内色氨酸代谢限速酶,其表达增强后可以通过多种机制诱导局部免疫耐受,为肿瘤的发生、发展乃至转移创造适宜的条件。
参考来源 - 吲哚胺·2,447,543篇论文数据，部分数据来源于NoteExpress
Interestingly, no indoleamine 2, 3-dioxygenase activity was detected in our conditions.
有趣的是，我们没有检测到吲哚胺2,3 -二氧化酶活性。
The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the oxidative cleavage of the indole ring of tryptophan.
吲哚胺2，3双加氧酶（IDO）是一种免疫调节酶，可催化色氨酸分子中吲哚环氧化裂解，从而沿犬尿酸途径分解代谢的限速酶。
Immunosuppression mediated by TLR was dependent on the production of immunosuppressive kynurenines by the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase-1 (IDO1).
TLR介导的免疫抑制反应不依赖于色氨酸代谢酶吲哚胺2，3加双氧酶1（IDO1）产生的免疫抑制物质犬尿氨酸。
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