I was in the depths of despair when the baby was terribly sick every day, and was losing weight.

宝宝每天都病得很重并且体重在下降的时候，我陷入绝望的深处。

《柯林斯英汉双解大词典》

A true friend will always extend a helping hand to you when you're in the depths of despair.

当你处于绝望的深渊时，真正的朋友总会伸出援助之手。

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I was in the depths of despair when the baby was sick.

孩子生病时我陷入了绝望的深渊之中。

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But when Robert Gates took over from Rumsfeld during the depths of American despair in Iraq, he soon began to doubt the relevance of the program to a world in which elusive adversaries were planting improvised explosives along every transportation artery in war zones.

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