In further experiments, they found that removal of these proteins depends on the chemical modification of the GluA1 protein. Mice lacking this chemical modification of GluA1 recovered fear memories induced by loud tones, whereas littermates that still had normal GluA1 protein did not recover the same fear memories. Huganir suggests that drugs designed to control and enhance the removal of calcium-permeable AMPARs may be used to improve memory erasure.
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