Without a steady supply of fresh blood, without the oxygen it carries, the human brain is quickly impaired. In four minutes, brain cells, starved for oxygen, begin to die, and serious brain damage result. In another is completely destroyed. This was the crux of a stubborn problem. The heart could not be taken out of action for more than fore minutes--very little time to repair a heart defeat. Until a solution could be found , operation on the open heart would be impossible.
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