An improved simplex method (ISM) based on Nelder and Meads simplex method (N-M SM) is presented for unconstrained function optimization.

针对无约束函数最优化问题，提出了一种能有效加快收敛速度的改进单纯形算法。

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The optimization problem with multiple constraints is treated by the compact constraint tactics and is solved by the improved simplex method.

对于多约束则采用了紧约束处理，并用修正的单纯形法进行优化设计。

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By using improved simplex method and residuals method, a calculation based on the parameters of compartment model of pharmacokinetics is presented.

基于改进的单纯形算法和残数法，对药物动力学房室模型中的有关参数计算进行了研究。

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