abstract:The insulin-linked polymorphic region (ILPR) is a regulatory sequence on the insulin gene starting at position -363 upstream from the transcriptional start location of the 5' region and consists of multiple repeats of a ACA-GGGGT(G/C)(T/C)GGG consensus sequence. The polymorphic aspect of this region is due to three possible combinations of sequences according to their length: 700bp, 1600bp and 2500bp.