Pittsburgh defenseman Deryk Engelland blocked it while lying on the ice, and a linesman handed the glove back to Fleury as the Penguins raced the other way.
Reimer was the best player on the ice for Toronto in all three periods, including a big glove save off Henrique three minutes into the second and another stop against Elias in the final minute.
Buffalo took the lead 3:29 into the second period when Vanek won a battle for the puck along the boards and sent a cross-ice pass to Flynn, who fired a slap shot from the top of the right circle over Nabokov's glove.