I can never, ever forgive him. I despise him.

我永远，永远都不会原谅他。我鄙视他。

《柯林斯英汉双解大词典》

I despise such people; they've no character.

我藐视这种人，他们没骨气。

《新英汉大辞典》

As to you, I despise you.

至于你，我看不起你。

youdao

Von Trier claimed each morning she would say "Mr von Trier, I despise you, " and spit at him.

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Because TV viewers like you and I despise them.

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As a journalist I despise email.

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