Preliminary studies on SAR of hypnotic activity revealed that the hypnotic activities and irritations of N-substituted oleamide derivatives and N-oleoyl-N? -substituted piperazine derivatives are both lower than those of their mother substances S01 and S07.
对催眠活性的试验结果显示：油酰胺和油酰哌嗪的氮原子被烷基或芳基取代后，催眠活性均较母体化合物降低，同时给药刺激性也降低。
参考来源 - 油酰胺衍生物的合成及催眠活性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
The dissertation mainly studied the influences of circadian rhythm system and GABAergic system on hypnotic activity of melatonin.
其中，褪黑素作为内源性催眠物质诱导生理性睡眠和调节睡眠-觉醒节律的作用尤其引人注目。
From above results, it is demonstrated that melatonin exhibits more significant hypnotic activity due to circadian rhythm system dysfunction.
提示当昼夜节律系统功能紊乱时，褪黑素能表现出更强的催眠作用。
Conclusion: Melatonin does not exhibit its potentiation sleeping time in mice through melatonin 3 receptor. Hypnotic activity of melatonin may be mediated through picrotoxin site on GABAA receptor.
结论：褪黑素延长小鼠睡眠时间的作用与褪黑素3型受体无关，而与GABAA受体关系密切，其作用主要由印防己毒素结合位点介导。
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