In the inflammatory pain rat model,the previous studys showed that i. t. CRH inhibited acetic acid injection-induced hyperalgesia,and direct influence on immunological function has been discovered recently.
在炎症痛大鼠模型上,以往研究显示,鞘内注射CRH能抑制痛敏。 最近还发现CRH能直接影响免疫功能。
参考来源 - 促肾上腺皮质激素释放激素在针刺镇痛与免疫调节中的作用及机制研究Pain and hyperalgesia was caused by injury of tissue and peripheral nerves.
组织损伤及外周神经损伤后可导致痛及痛过敏。
参考来源 - 福尔马林炎性痛诱导大鼠脊髓后角和海马PKC表达上调Furthermore, astrocyte activation is sufficient to result in hyperalgesia, which can be effectively alleviated by interruption of glial including astrocytic function.
星形胶质细胞激活本身足以导致痛觉过敏,而干扰胶质细胞包括星形胶质细胞功能的药物亦能有效抑制痛觉过敏。
参考来源 - 强直刺激坐骨神经诱导脊髓痛敏神经元可塑性机制·2,447,543篇论文数据,部分数据来源于NoteExpress
应用推荐