No matter how difficult the question is, I won't surrender to it.

不管问题多难，我都不会屈服。

youdao

The difficult question is how to find that profitable niche and protect it.

这个难题是：如何找到有利可图的利基市场并加以保护。

youdao

The likely answer is a little of both, but the question highlights how difficult it can be to have a perspective on what’s big and what’s small.

答案可能是这两种因素都有一点，但是这个问题突出显示了要区别什么是大什么是小这个问题有多难。

youdao

I never met anybody who seemed more like an author than this person, and yet he's raising the question whether there is any such thing, or in any case, the question how difficult it is to decide what it is if there is.

我从来没有遇见过比他看起来更像作家的人，现在他提出了一个问题，问无论如何，如果有这么个东西的话那么决定它是什么有多难。

耶鲁公开课 - 文学理论导论课程节选

Now the question is "how does it expand" and "why is it so difficult for us to understand, accept, assimilate and live according to the fact that we can make a difference, if we understand that what we need to understand is how change happens.

问题是“它如何扩大“,以及为什么我们难以理解，我们能够做出改变这个事实,并接受，被同化以及据此生活，如果我们能了解我们需要理解的,是改变如何发生。

哈佛公开课 - 幸福课课程节选

The difficult question is how will Newark turn the privately owned, illiquid shares of Facebook into usable cash for their troubled school system?

FORBES: How Will Newark Turn Zuckerberg's $100 Million Worth Of Facebook Shares Into Cash?

When faced with planning a new data center the question of how much space will be needed is potentially the most difficult to determine.

FORBES: The Case for the Infinite Data Center

One, admittedly very difficult, question is how to charge market prices for energy to those who can afford them, while protecting the really poor from freezing in winter.

ECONOMIST: Russia��s infrastructure