Despite her handicap, Jane is able to hold down a full-time job.

简尽管有生理缺陷，却能够保住一份全职工作。

《牛津词典》

Hard times may hold you down at what usually seems like the most inopportune time, but you should remember that they won't last forever.

困难时期可能总在最不合时宜的时候阻碍你，但请相信，这样的时刻不会一直持续下去。

youdao

I used to hold down a full-time job whilst being busy and active outside work.

我曾经拥有一份全职工作，同时也积极而繁忙的参与其他外部工作。

youdao

And many of them are doing all of this while trying to hold down full-time jobs.

WHITEHOUSE: First Lady Michelle Obama and Dr. Jill Biden Speak on Military Spouse Employment | The White House

She has very long hair, you see, which needs to dry naturally, and since this process takes at least four hours a day, there's basically no way she can hold down a full-time job.

BBC: You COULD make it up

Shevchenko, AC Milan's second-most prolific goalscorer of all-time, with 127 goals from 208 games, was unable to hold down a regular spot at Chelsea, scoring only nine goals in his 47 Premier League appearances, but maintains he enjoyed his time at the club.

BBC: Shevchenko completes Milan move