It means to travel or to leave a place, as suggested in this song, "Hit the Road."

VOA: special.2009.09.20

One is hit the road.

VOA: special.2009.09.20

Snowfall hit road-users and flights out of Belfast International Airport and George Best Belfast City Airport on Friday.

BBC: Translink coach on snowy road

Remarkably, this Fiorentina side is packed with players who hit road bumps, whether through injury or poor performance, in their careers.

WSJ: Mortella's Approach Paying Off for Italian Soccer's Fiorentina

The Peugeot they were in left the road, hit a road sign and ended up in a field.

BBC: Tributes paid to couple killed in Hoo crash