In 2003, "The Devil Wears Prada" reached the top of the best-seller lists and went on to inspire the hit 2006 film starring Meryl Streep and Anne Hathaway.

CNN: 'Devil Wears Prada' book sequel in the works

That's not enough to make up for the hit coming in 2006, when Merck's top seller, the cholesterol-lowering pill Zocor, loses patent protection.

FORBES: Magazine Article

At 1.5 times book value, Merrill is trading at half the levels it hit in 2000 and 2006.

FORBES: No Thain, No Gain