AIM: to investigate the effect of histamine receptor antagonist on airway remodeling and acid-base imbalance in asthma of guinea pig.

目的：探讨组胺受体拮抗剂对哮喘豚鼠气道重塑和酸碱平衡紊乱的防治作用。

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METHODS:Guinea pigs were divided into 5 groups: the normal control group, the asthma model group, the continued asthma model group, histamine group and histamine receptor antagonist group.

方法：将豚鼠分为正常对照组、哮喘模型组、哮喘模型延续组、组胺组、组胺受体拮抗剂组。用高效液相色谱法检测血清组胺浓度；

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Background: As one of the histamine H_2 receptor antagonist, the oral absorption of famotidine is not complete, its bioavailability is about 37%-50%.

背景：法莫替丁作为组胺H_2受体拮抗剂，其口服吸收不完全，生物利用度约为37% - 50%。

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