• 正己醛 - 引用次数：8

  After that, a stereoselective synthesis of (-)-(4E,7S)-7-methoxydodec-4-enoic acid which is the acid portion of malyngamides U and V was accomplished in eight steps from hexanal in 24% overall yield. The key steps involved the catalytic asymmetric allylation of hexanal and the coupling reaction of a chiral alkyne and a protected bromide in the presence of t-BuLi.

  其次,对malyngamides U,V的手性长链脂肪酸部分(-)-(4E,7S)-7-甲氧基-4-十二烯酸进行了合成,以正己醛的不对称烯丙基化反应和在t-BuLi存在下的手性末端炔和保护的3-溴-1-醇进行的S_N2偶联反应为关键步骤,通过8步反应以24%的总产率完成了其合成。

  参考来源 - 海洋天然产物malyngamides U，V及共轭多烯酰胺生物碱的合成
  己醛
• 己醛

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