重组腺病毒介导的高抵抗素血症对小鼠糖代谢的影响 - docin.com豆丁网 葡萄糖-6-磷酸酶（G6Pase）和磷酸烯醇式丙酮酸羧激酶（PEPcK）表 达，从而引起糖异生增多，肝糖输出（hepaticglucoseoutput，HGo）增多，在 体外培养的肝细胞的研究中亦得出相近结果． 这些研究结果曾一度使人们认为可以解开“肥胖与糖尿
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Objective To study the relationship between hepatic insulin resistance induced by high fat diet and the expression of genes involving hepatic glucose output.
目的观察高脂饮食饲养造成的肝脏胰岛素抵抗与肝糖输出有关的调控基因表达的关系。
Loss of first-phase response has metabolic consequences: lack of rapid insulinization of the liver delays the suppression of hepatic glucose output and causes therefore postprandial hyperglycemia.
第一相胰岛素反应丧失的后果为肝脏未能迅速胰岛素化，延迟了对肝葡萄糖输出的抑制，从而引起餐后高血糖。
Infact, insulin resistance in liver contributes to the excessive hepatic output of glucose, which is highly correlated with hyperglycemia in type 2 diabetes.
事实上，2型糖尿病的高血糖同肝脏胰岛素抵抗所致肝糖过度输出有着紧密的关系。
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