The progressive result is an accumulation of fatty deposits called plaque that can rupture or have their caps shear off, causing clots that lead to heart attacks.

Donohue博士说，进一步恶化的结果是称之为血斑的脂肪沉积开始积累、破裂、剥落，最后形成导致心脏病发作的血栓。

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Over time, the buildup of plaque deposits can rupture and cause total blockage of the blood flow to the heart.

久而久之，血小板沉积物逐渐积累，会导致流往心脏的血液完全阻塞。

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Once that plaque builds up, it can rupture and completely block the artery, cutting off the blood supply to your heart.

一旦斑块堆积，则会损伤并完全阻塞动脉，造成心脏缺血。

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Just last month, researchers led by Armin Arbab-Zadeh of Johns Hopkins University School of Medicine in Baltimore published a comprehensive review of the biology of heart attacks in the journal Circulation, which said that vulnerable plaques often rupture without causing a heart attack and that a "perfect storm" of other conditions is required before one occurs.

WSJ: Predicting Who Will Have Heart Attacks

These high leukotriene levels, DeCode researchers believe, inflame artery walls, increasing the odds that arterial plaques will suddenly rupture and cause heart attacks or strokes.

FORBES: Magazine Article

New catheter-based imagers aim to improve IVUS by letting doctors distinguish stable plaque, safely ensconced in scar tissue, from the inflamed plaque that is more likely to rupture and trigger a heart attack.

FORBES: Peeking at Plaque