He cannot possibly take on any further engagements; he's plenty on his plate as it is.

他实在不能承担更多的工作了；他目前要做的事已经够多的。

youdao

For he will have been elected on such ground that he cannot possibly save the Union afterwards."

VOA: special.2009.12.10

While a future Congress could, theoretically, bring the Accountable Care Act to an end, and while the Supreme Court may yet destroy part or all of the law before Perry needs to make good on a promise that he cannot possibly keep, the simple fact is that there is really no impact on the law that might result from such an executive order.

FORBES: Rick Perry Clueless On Use Of Executive Presidential Powers To Kill Obamacare

If a child is not present at school, he or she cannot possibly learn.

CNN: How to get teachers to teach and students to learn

"It's just something the city cannot possibly afford" without a dramatic tax increase, he said.

WSJ: Contracts a question as NYC mayor presents budget