Have you lost or gained weight recently within 5% in either direction, and have you noticed a significant increase or decrease in appetite?

你是否减少或增加了5%的体重，你是否注意到你有在食欲方面明显的增加或减少？

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Hidden away, they have lost their direction and are in desperate need of hope.

慢慢地，他们失去了方向，现在正急切地需要希望。

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As a result, our self-esteem takes a big hit because we have lost our sense of direction.

结果因为失去了方向感，我们的自尊受到打击。

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The show helped steer her family in a healthier direction, she said, and they all have lost significant amounts of weight.

CNN: 'Big' concerns surround new reality show

As a result, the developers have limited control over a game's direction, and it is never really won or lost.

ECONOMIST: Computer games

In defending what might seem a lost or losing cause, I have adopted the usual conservative posture of sadness at the pace and direction of current events.

NPR: Book Argues for Retaking the 'Conservative Soul'