Despite initial fears, biotechnology has not, up to now, caused any serious problems.

除了最初的恐惧感，生物技术到目前为止还没有产生任何严重的问题。

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The competition for the best players has forced up salaries for all players, not just free agents.

VOA: special.2010.07.26

She's a poet and she has an impeccable ear, but this fiercely virginal Lady has not up to this point even begun to develop her other sensory realms.

她是位诗人，有着完美的听觉，但是这位贞洁的女士直到此刻,也没有开始培养她的其他感官领域。

耶鲁公开课 - 弥尔顿课程节选

If something has a high ionization energy, it means that it really, really, really does not want to give up an electron.

如果某个东西有很高的电离能，这意味着它非常非常，非常不愿意失去一个电子。

麻省理工公开课 - 化学原理课程节选

Another thing that is worth noting about this news: contrary to what many people believe, the NIH has not up until now been deeply involved in the expensive and difficult process of discovering drugs.

FORBES: The NIH Gets Into The Drug Development Business

Still, Mr Maroun has not given up, and has managed to force the question of the new river crossing on to the state ballot this November.

ECONOMIST: Infrastructure

Dean has not given up his stand and has returned to the core of his campaign, trekking door-to-door seeking support.

CNN: Candidates reach out across New Hampshire