We tested the activity of our safety switch by introducing the gene into donor t cells given to enhance immune reconstitution in recipients of haploidentical stem-cell transplants.
我们将基因导入用于加强单倍同一性干细胞移植受者免疫重建的供体T细胞，以此对该安全开关的活性进行了检验。
Methods: In this pilot study, 58 patients, 33 with high-risk or advanced leukemia, were transplanted with cells from an HLA-haploidentical family donor with at least 1 of 6 loci mismatched.
方法：5 8例血液恶性肿瘤患者，33例为高危或难治复发白血病，接受了至少一个HLA位点不合的家庭供者造血干细胞移植。
Besides technological advances, choosing the most appropriate donor is also an important factor to overcome the HLA barriers in haploidentical HSCT.
为克服供受体h LA差异对半相合移植的不利影响，除改良移植技术之外，选择最为合适的供体也是决定手术成败的重要因素。
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