Hantzsch pyridine synthesis
- 汉奇吡啶合成反应（Hantzsch吡啶合成是一种多组分反应，通过甲醛、β-酮酯和含氮化合物反应得到二氢吡啶类，再通过氧化得到吡啶衍生物。该反应产物可用作医药上的钙通道阻滞剂。反应可在水溶液中进行，微波辐射有助于反应进行）
Hantzsch pyridine synthesis
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abstract:
The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia. The initial reaction product is a dihydropyridine which can be oxidized in a subsequent step to a pyridine.
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