(tuberoussclerosis)基因定位于9q34或16p13.3,为肿瘤抑制基因,分别命名为TSC1和TSC2;TSC1基因编码错构瘤蛋白(Hamartin),TSC2基因编码马铃薯球蛋白(tuberin),它们通过抑制mTOR信号通路来控制细胞的增生和分化,调节细胞生长。
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Anti-Hamartin Polyclonal Antibody 抗Hamartin多克隆抗体
·2,447,543篇论文数据,部分数据来源于NoteExpress
This data complements Drosophila genetics studies suggesting the possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway (8-10).
这些数据和果蝇( Drosophila)遗传学研究表明tuberin-hamartin 复合物可能在PI3K/AKT 介导的胰岛素通路中取作用(8-10)。
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When the researchers prevented the cells from producing hamartin, they died just like other cells.
BBC: Brain's 'stroke shielding' cracked
Experiments on rats showed that these surviving-cells started producing a protein called hamartin - which forces cells to conserve energy.
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