Wee are faced with both a rare opportunity and grave challenges.

我们既面临难得的机遇，也面临严峻的挑战。

youdao

The world is far from being tranquil and mankind is faced with many grave challenges.

世界还很不安宁，人类面临着许多严峻挑战。

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The world faces too many grave challenges for us to allow culture to be an obstacle to progress.

世界范围内，有太多的严峻挑战需要我们应对，在这种情况下，文化差异难以成为我们前进的障碍。

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Not even halfway into the Obama administration, there are some very grave challenges that have gotten worse.

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We need to find new pathways of international cooperation that respond more effectively to the grave challenges caused by the growing interdependence of nations.

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And even as there are grave challenges and great uncertainty, I am confident that the Egyptian people can shape the future that they deserve.

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