生命科学 关键词：乳腺癌易感基因1；基因组稳定性；突变；乳腺癌 [gap=804]Key words: breast cancer susceptibility gene 1; genome stability; mutation; breast cancer
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Cancer is one of the gene diseases. The genome stability is closely associated with the occurrence of cancers.
肿瘤是一种基因病，基因组的稳定与否和肿瘤的发生密切相关。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair.
乳腺癌易感基因，BRCA1，编码一种E3泛素连接酶，BRCA1通过调控DNA损伤反应和DNA修复维持基因组的稳定性。
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