基因置换（gene replacement）是以大换血的方式将将整个致病基因替换为正常基因。理论上讲，基因修正与置换是目前最理想的基因治疗方式，但由于其中所需的同源...
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目前，修正基因治疗方案根据其目的可分为五类：（1）基因替换（gene replacement）／基因修复（genecorrection）：是指用特异的功能正常的基因取代致病 基因，一般将正常基因导入基因缺陷的靶细胞内，经同源重组进...
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targeted gene replacement 目标基因替换 ; 定向基因置换
targeted gene replacement and integration 基因定位置换整合
pcr-mediated gene replacement pcr介导的基因置换
by gene replacement 经基因置换
target gene replacement 靶基因置换
gene-replacement vector 置换型载体
Mitochondrial Gene Replacement 线粒体基因置换
gene disruption and replacement 基因破坏和基因替换
In this study, PCR-mediated gene replacement technique was applied in theconstruction nsdA gene disruption strain.
本研究采用了PCR介导的基因置换技术构建nsdA基因中断菌株。
参考来源 - nsdA基因中断及orfX基因整合表达对阿维链霉菌次级代谢的影响At present, wide-type P53 gene replacement therapy is among focus of tumor gene therapy, of which, recombinant adenovirus-P53 is the most commonly used.
目前,野生型P53基因替代疗法是肿瘤基因治疗的研究热点,而重组人P53腺病毒液则是最常用的治疗方式。
参考来源 - 重组人P53腺病毒液对人卵巢癌细胞株生长抑制及凋亡的作用研究By using the gene replacement construct pHZ2029, approximate 80kb fragment from chromosome was substituted by an apramycin resistance gene (aac(3)IV) ofpHZ2029 through double crossing over by homologous recombination event.
通过基因置换获得缺失约80kb片段的突变菌株HJ5。
参考来源 - 抗生素FR·2,447,543篇论文数据，部分数据来源于NoteExpress
Targeted gene replacement (TGR) is an important technique for gene function analysis.
目标基因替换是基因功能分析的重要手段。
The observations suggest that the tumor suppressor gene CDKN2 is a potential candidate for ge ne replacement therapy of NSCLC.
结果表明肿瘤抑制基因CDKN2可望成为NSCLC基因替代治疗的候选基因。
Gene therapy is a permanent replacement of a defective gene, usually treating an inherited disorder and usually using a viral vector.
基因治疗通常是利用病毒载体永久性地替换缺陷基因来治疗遗传性疾病。
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