Lastly, the relationship between gene mutation rate and mutation probability and the application of the model in the analysis of multiple characters are discussed.

最后讨论了基因突变率与突变概率间的相互关系及本模型在多性状分析中的应用问题。

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As a result of the early gene bombardment from mitochondria, the mutation rate surely shot through the roof.

早期线粒体基因狂轰滥炸的结果，就是突变率高到爆棚。

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If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.

双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。

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In the trial, which included 55 patients, tumors dramatically shrank in 9 of 16 very advanced patients with the gene mutation who got high doses--a better response rate than doctors have remembered seeing in a trial for advanced melanoma.

FORBES: American Society of Clinical Oncology