Furane or thiophene ring substituted for benzene ring of benzylidene, activity of the compounds would be increased. Furthermore, the compounds containing hyper-conjugate skeleton were more potent.
取代苯亚甲基的苯环的对、间位取代给电子基团时,活性较好,邻位取代的活性降低;苯环取代吸电子基团时活性相对较差,而无取代时几乎无活性;芳香环为呋喃、噻吩的活性高于苯环;共轭程度高的化合物,活性较好。
参考来源 - 选择性COX·2,447,543篇论文数据,部分数据来源于NoteExpress
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