In the late 1800s English physiologist John Langley discovered the muscular nicotinic receptor when he tied a frog muscle to a round drum, put nicotine on the muscle and saw it contract.
An ad agency I was working with a decade ago presented, as part of a new round of work, a rough cut of a crazy video featuring a frog, hot pink background, and loud pulsating music by Joan Jett and the Blackhearts.