Objective To investigate the neuroprotective effects of flunarizine (FNZ) and lamotrigine (LTG), and their combination on the hypoxic-ischemic brain damage in fetal rats.

目的研究氟桂利嗪(FNZ)、拉莫三嗪(ltg)及两药联合经孕鼠给药，对胎鼠宫内缺血缺氧性脑损害的保护作用。

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Objective To study the dual effects of calcium antagonists on ischemic hypoxic injury of hippocampal neurons cultured in vitro by using flunarizine (FNZ) and the mechanism of its action.

目的利用氟桂利嗪(FNZ)研究钙离子拮抗剂对体外培养海马神经元缺血缺氧损伤的作用及其作用机制。

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The results suggested that the increased endothelin level of ischemia brain territory was important factor leading to ischemic neuronal injury, and FNZ had protective effects on cerebral ischemia.

上述结果提示：缺血脑组织内皮素含量升高是导致缺血神经元损伤的重要因素，氟桂嗪对脑缺血有保护作用。

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