• 氟化 - 引用次数：3

  The substituted groups of 2-aminopyrimidine derivatives were mainly alkyl, alkoxyl or halogen, while trifluoromethy-containing heterocyclic compounds were seldom reported. The synthesis routes were often heterocyclization first, and fluorization was followed.

  现有嘧啶类衍生物的取代基团大都为烷基、烷氧基和卤素原子，含有三氟甲基的嘧啶类衍生物的报道比较少，且合成方法多为先合成杂环再经过氟化的方法。

  参考来源 - 三氟甲基嘧啶衍生物及其磺酰脲类化合物的合成研究

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