This method can realize net shape forging by optimizing preform die shape. Flashless final forging with complete die fill and without folding-over defect can be obtained.

该方法通过优化设计预成形模具形状，可实现精形终锻，得到无飞边、完全充满型腔和无折叠的终锻件。

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The choice of purification methods and the source of the drug will determine the nature and amount of contaminants in the final medicine. (Nothing is ever 100% pure.) Moreover, protein folding, various kinds of enzymatic modifications and impurities inevitably introduce variation, sometimes with unexpected results.

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