With its traditional approach, Big Pharma is not coming up with new drugs fast enough to fill its emptying pipeline.

靠传统方法，大型制药公司无法及时推出新药以填补空缺的产品线。

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Moving out from the center and filling in the open space any way you are driven to fill it, start to write down, fast, as many related concepts or terms as you can associate with the central topic.

从中心开始到周围的任何空间中，尽可能快的写下与主题相关的概念和术语。

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While that may be an exaggeration, new business owners are frequently too optimistic about how soon they will begin to fill their cash pipeline and how fast the money will flow.

然而听起来可能有点夸张，新的创业者总是经常会乐观的认为他们会很快的填补资金流和并自信的以为资金流会运作地很快。

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Yahoo Chief Executive Marissa Mayer's deal for Tumblr gives Yahoo, one of the original big Internet companies, a fast-growing Web service that could fill one of its many holes namely, the lack of a thriving social-networking and communications hub.

WSJ: Yahoo Deal to Buy Tumblr Shows Power Shift

Flower bouquets are on the counters and tabletops and the communal tables facing the open kitchen fill up fast for pre-dinner cocktails.

BBC: Business trip: Quito

Nook Tablet has potential to fill a profitable niche in a still-fast-growing market.

WSJ: HEARD ON THE STREET: Barnes & Noble Finds Nook in Book Market