It is very subtle, but so often because there is no respect or care for yourself that you feel angry or fall into despair.

很微妙的是，人们感到愤怒或陷入绝望往往是由于不够尊重或爱护自己。

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But sometimes the music or what he was reading would all of a sudden cease to act on him or, worse, he would fall into despair or irritation, no longer able to see the bright horizon promised to him by music, by reading, by the art of imagination and the excitement of a sensitive heart.

NEWYORKER: Among Animals and Plants

But human beings fall easily into despair, and from the very beginning we invented stories that enabled us to place our lives in a larger setting, that revealed an underlying pattern, and gave us a sense that, against all the depressing and chaotic evidence to the contrary, life had meaning and value.

NPR: Karen Armstrong: Myths and the Modern World

She said the changes proposed by her bill would help inform individuals of the full range of agencies able to support them "instead of allowing them to fall into the hands of some of the fee-charging companies who propel them into further debt and despair".

BBC: Ten Minute Rule Bill