Sorrow is basically due to death of a loved one, failure and despair.

痛苦是因为爱人的死亡。失败和失望。

youdao

I will never yield to failure and despair no matter what challenges I meet.

无论我面对什么样的障碍，我决不向失败与绝望低头。

youdao

Sorrow is basically coming out when something is out of your plate like death of a loved one, failure and despair.

当一些不如意的事情发生的时候，比如所爱的人的离世，人生中的失败和绝望，此时，你会感到痛苦。

youdao

At the start of the 21st century, Freetown symbolises failure and despair.

ECONOMIST: Hopeless Africa